Profile of Dr. Md. Elias Al-Mamun

... Name Dr. Md. Elias Al-Mamun
Designation Professor & Chairman
Last Degree B. Pharm (Hons); M. Pharm (DU); PhD (Tohoku, Japan); Post-Doc (JSPS, Tohoku, Japan)
   

Academic Background

 

Doctor of Philosophy (PhD)         Institute            :           Tohoku University, Sendai, Japan
                                                        Department      :           Cardiovascular Medicine
                                                        Faculty             :           Graduate School of Medicine
                                                        Session            :           October 2009-March 2010 (Research Student)
                                                                                              April 2010-March 2014 (PhD Student)
                                                       Passing Year    :           March 26, 2014.
                                                       Thesis Title       :           Combination Therapy with a Rho-kinase Inhibitor (Fasudil) and a PDE5 Inhibitor (Sildenafil) Ameliorates Monocrotaline-Induced Pulmonary Hypertension and Survival in Rats.
                                                      Thesis Supervisor:         Prof. Hiroaki Shimokawa MD, PhD.
 
 
M. Pharm (Thesis Group)           Institute             :           University of Dhaka, Dhaka, Bangladesh
                              Department      :           Pharmaceutical Technology
                                                       Session            :           1999-2000 (Started on October 21, 2003)
                                                      Year of Exam    :           2000 (Held in November 2004)
                 Result                :           First Class First (Published on May, 2006) 
                                                      Marks Obtained :           74.33 %
                                                       Thesis Title       :           In vitro Study on Dexamethasone and Tamsulosin Release kinetics from Biodegradable PLGA in situ Implants.
                                                     Thesis Supervisor:         Prof. Dr. Reza-ul Jalil.   
 
B. Pharm (Hons)                            Institute             :           University of Dhaka, Dhaka, Bangladesh
                                                        Department       :           Pharmacy
                                                          Year                 :           1999 (Held in 2001)
                                                        Result                :           First Class 2nd (Published on December 2002).
                                                        Marks Obtained :           70.11 %
                                                         Project Title       :           Phytochemical and Biological Investigation on Hedyotis corymbosa.
                                                       Project Supervisor:         Dr. Monira Ahsan.
 
H.S.C.                                               Institute              :           Dinajpur Govt. College, Bangladesh
                                                          Group                :           Science
                                                          Board                :            Rajshahi
                                                           Year                 :           1994                
                     Result               :           1st division
                                                         Marks Obtained :           81.4 %

 

S.S.C.                                                Institute            :           Birganj Govt. High School, Bangladesh
                                             Group                :           Science
                                              Board                :           Rajshahi
                                               Year                 :           1992
                                                          Result               :           1st division
                                                         Marks Obtained :           87.1 %

Professional Experiences

Researcher (Post-Doctoral Fellow)
        JSPS Postdoctoral Fellowship for Foreign Researchers’ 2014
        (Pathway to University Positions in Japan)
        Department of Cardiovascular Medicine
        Graduate School of Medicine
        Tohoku University, Sendai, Japan 980-8574.
         Duration: From November 22, 2014 to December 31, 2014; and
                         From March 1, 2016 to January 22, 2018.
 
Associate Professor
Department of Pharmaceutical Technology
Faculty of Pharmacy, University of Dhaka, Dhaka-1000.
Duration: From August 14, 2014 and onwards
 
Assistant Professor
Department of Pharmaceutical Technology
Faculty of Pharmacy, University of Dhaka, Dhaka-1000.
Duration: From November 20, 2008 to August 13, 2014.
*Study Leave from 6th October 2009----5th April 2014.
 
Lecturer
Department of Pharmaceutical Technology
Faculty of Pharmacy, University of Dhaka, Dhaka-1000.
Duration: From November 22, 2006 to November 19, 2008
 
Assistant Commissioner and Magistrate
Office of the Deputy Commissioner, Sherpur
Ministry of Public Administration, Government of Bangladesh
Duration: From July 02, 2005 to November 22, 2006.
 
Product Officer
Product Department & International Marketing
The ACME Laboratories LTD. Dhaka, Bangladesh.                
Duration: From April 2003 to July 2005
 
Product Executive
Product Management Department
Globe Pharmaceuticals LTD. Dhaka, Bangladesh.
Duration: From August 2002 to March 2003

List of Publications   

 

Original Articles:

  • Shinichiro Sunamura, Kimio Satoh, Ryo Kurosawa, Tomohiro Ohtsuki, Nobuhiro Kikuchi, Md. Elias-Al-Mamun, Toru Shimizu, Shohei Ikeda, Kota Suzuki, Taijyu Satoh, Junichi Omura, Masamichi Nogi, Kazuhiko Numano, Mohammad Abdul Hai Siddique, Satoshi Miyata, Masahito Miura, Hiroaki Shimokawa: Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice.  Accepted and published in PNAS. (July 9), 2018. DOI: www.pnas.org/cgi/doi/10.1073/pnas.1721298115.  (Epub ahead of print)
  • Masamichi Nogi, Kimio Satoh, Shinichiro Sunamura, Nobuhiro Kikuchi, Taijyu Satoh, Ryo Kurosawa, Junichi Omura, Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, Kazuhiko Numano, Shun Kudo, Satoshi Miyata, Masatoshi Akiyama, Kiichiro Kumagai, Shunsuke Kawamoto, Yoishikatsu Saiki, Hiroaki Shimokawa: SmgGDS Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells.  Accepted and published in Circulation. (June 19), 2018. DOI: https://doi.org/10.1161/CIRCULATIONAHA.118.035648. Circulation. 2018; CIRCULATIONAHA.118.035648.  (Epub ahead of print)
  • Nobuhiro Kikuchi, Kimio Satoh, Ryo Kurosawa, Nobuhiro Yaoita, Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Satoshi Miyata, Yoshiro Saito, Yasushi Hoshikawa, Yoshinori Okada, Hiroaki Shimokawa: Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target.  Accepted and published in Circulation. (April 10), 2018. DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.033113. Circulation. 2018; CIRCULATIONAHA.117.033113.  (Epub ahead of print)
  • Md. Elias-Al-Mamun, Abdullah Al Mamun (Jan, 2018): Gift as a Promotional Material and the Related Prescription Behaviour of Physicians in Bangladesh Pharmaceutical Market. World Journal of Pharmacy and Pharmaceutical Sciences. 7(1); 106-119.
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa, Kazuhiko Numano, Elias Al-Mamun, Mohammad Abdul Hai Siddique, Shinichiro Sunamura, Masamichi Nogi, Kota Suzuki, Satoshi Miyata, John Morser, Hiroaki Shimokawa (April, 2017): Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target.  Circ Res. 120; 1246-1262. DOI: 10.1161/CIRCRESAHA.117.310640.
  • Muhammad Rashedul Islam, Shadid Uz Zaman, Md. Elias-Al-Mamun, Mohammad Aziz Ullah (Jan 2017): Prescribing Trends of Anti-Ulcerant Drugs by Generic Names in Dhaka City of Bangladesh. World Journal of Pharmaceutical Research. 6(1); 41-49.
  • Muhammad Rashedul Islam, Md. Mizanur Rahman Moghal, F.M. Shah Noman Ul Bari and Elias Al Mamun (Dec 2016): Design and Development of Bi-layered Sustained Release Azithromycin Tablets. Dhaka Univ. J. Pharm. Sci. 15(2); 227-234.
  • Md. Elias-Al-Mamun, Tushar Saha, Muhammad Rashedul Islam (Sep 2016): Initiation and maintenance of diseases and diagnostics database for Bangladeshi individuals.  Am. J. Pharm Health Res. 4(9); 30-42.
  • Muhammad Rashedul Islam, Md. Elias-Al-Mamun, and Md. Mizanur Rahman Moghal (July 2016):  Release modification of indomethacin controlled release press coated tablets. Bangladesh Pharmaceutical Journal. 19(2); 219-225.
  • Muhammad Rashedul Islam, Md. Elias-Al-Mamun, Md. Mizanur Rahman Moghal and Md. Habibur Rahman (Dec 2015): Development and evaluation of indomethacin controlled release press coated tablets. Dhaka Univ. J. Pharm. Sci. 14(2); 187-192.
  • Nazia Tajrin, Md. Elias-Al-Mamun, Md. Habibur Rahman and Md. Selim Reza (June 2015): Effect of channeling agents on release kinetics of stavudine from methocel K100 LVCR and ethocel 20 cps based matrix tablets. Dhaka Univ. J. Pharm. Sci.  14(1); 91-101.
  • Md. Abdullah Al Mahmud, Subrata Bhadra, Afroza Haque, Md. Elias-Al-Mamun and Syed Shabbir Haider (June 2014): Development and Validation of HPLC Method for Simultaneous Determination of Gliclazide and Enalapril Maleate in Tablet Dosage Form. Dhaka Univ. J. Pharm. Sci.  13(1); 51-56.
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Sota Nakajima, Toru Shimizu, Shohei Ikeda, Md. Elias-Al-Mamun, and Hiroaki Shimokawa (May 2014):  Role of Endothelial Nitric Oxide Synthase and Collagen Metabolism in Right Ventricular Remodeling due to Pulmonary Hypertension.  Circ J  78(6); 1465-74.
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Satoshi Miyata, Yoshihiro Fukumoto, and Hiroaki Shimokawa (April 2014):  Combination Therapy with Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension and survival in rats.  Circ J  78(4); 967-976.
  • Md. Omar Faruqe, Md. Elias-Al-Mamun and Reza-ul Jalil (June 2013): Evaluation of the Dissolution Profile of Hard Gelatin Capsule Filled with Ibuprofen Liquid. CDR J. 5(1): 11-18.
  • Md. Elias-Al-Mamun, Md. Asaduzzaman, Md. Saiful Islam and Reza-ul Jalil (August 2012): Effect of Hydrophobic Excipients on Release Kinetics of Ciprofloxacin from Kollidon® SR Embedded Matrix Tablets.  Asian J Pharm Clin Res.  5(3): 51-55.
  • Nahid sharmin, Md. Elias-Al-Mamun, Md. Saiful Islam, and Reza-ul Jalil (June 2011). Preparation and Characterization of Lidocaine Double Layer Buccal Tablet using Mucoadhesive Carbopol® Polymer.  Dhaka Univ. J. Pharm. Sci. 10(1): 29-34.
  • Md. Elias-Al-Mamun, Afroza Haque and Syed Shabbir Haider (March 2011): Development and Evaluation of Combined Gliclazide and Enalapril Maleate Immediate Release Tablet. J. Pharm. Sci. & Res.  3(3): 1103-1109.
  • Nahid sharmin, Md. Elias-Al-Mamun, Reza-ul Jalil (July 2010): A Novel Method to Study the Effect of pH and Excipients on Water Uptake and Swelling Behavior of Carbopol Polymers. Bangladesh Pharmaceutical Journal. 13(2): 1-7.
  • Md. Asaduzzaman, Md. Elias-Al-Mamun, Md. Saiful Islam, Reza-ul Jalil (December 2009): Effect of HPMC 4 cps and Carbopol 974p NF on Release Kinetics of Ciprofloxacin from Kollidon® SR Embedded Matrix Tablets. J. Pharm. Sci. & Res. 1(4): 137-145.
  • Md. Elias-Al-Mamun, Humaira Afreen Khan, Irin Dewan and Reza-ul Jalil (October 2009): In vitro Study on Tamsulosin Release Kinetics from Biodegradable PLGA In situ Implants. Pak. J. Pharm. Sci.  22(4): 360-367.
  • Irin Dewan, Md. Elias-Al-Mamun and Reza-ul Jalil (December 2008): Studies on Swelling Behavior of HPMC based Matrix Tablets by the Application of Digital Imaging Technique. Dhaka Univ. J. Pharm. Sci. 7(2): 169-175.
  • Irin Dewan, Md. Elias-Al-Mamun and Reza-ul Jalil (December 2007): In vitro Release Kinetics of Progesterone from Biodegradable In situ Implant System. Dhaka Univ. J. Pharm. Sci. 6(2): 99-103.
  • M Elias-Al-Mamun, M Hazrat Ali, Monira Ahsan, Nazmul Qais and Rasheduzzaman Chowdhury (June 2004): In vitro Antibacterial Activity of the Crude Extracts of Hedyotis corymbosa and Elaeocarpus robustus. Bangladesh J  Microbiol. 21(1): 42-43.

 

 List of Abstracts at Scientific Sessions/Meetings: 

  • Md. Elias Al-Mamun, Kimio Satoh, Taijyu Satoh, Nobuhiro Yaoita, Mohammad Abdul Hai Siddique, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa, Shinichiro Sunamura, Masamichi Nogi, Tomohiro Otsuki, Hiroaki Shimokawa (2017): Rivaroxaban Prevents the Development of Chronic Thromboembolic Pulmonary Hypertension in Mice- Novel Beneficial Effects of the FXa Inhibitor. e-Poster presented at Moderated Poster Session (presentation number P4926) at scientific congress by European Society of Cardiology (ESC) in Fira Gran Via, Barcelona, Spain; August 26-30.
  • Masamichi Nogi, Kimio Satoh, Shun Kudo, Junichi Omura, Nobuhiro Kikuchi, Taijyu Satoh, Shinichiro Sunamura, Ryo Kurosawa, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Tomohiro Otsuki, Hiroaki Shimokawa (2017): Protective Roles of small GTP-binding Protein GDP Dissociation Stimulator Against Angiotensin II-induced Thoracic Aortic Aneurysm Formation and Rupture in Mice- A Possible Novel Therapeutic Target. e-Poster presented at Best Poster in Atherosclerosis Session (presentation number P5164) at scientific congress by European Society of Cardiology (ESC) in Fira Gran Via, Barcelona, Spain; August 26-30.
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa, Shinichiro Sunamura, Masamichi Nogi, Tomohiro Otsuki, Satoshi Miyata, Hiroaki Shimokawa (2017): Thrombin Activatable Fibrinolysis Inhibitor Promotes Development of Chronic Thromboembolic Pulmonary Hypertension-A Possible Novel Therapeutic Target. Young Investigator Award Session Basic Science Finalist Lecture ( presentation number 1983) presented at scientific congress by European Society of Cardiology (ESC) in Fira Gran Via, Barcelona, Spain; August 26-30.
  • Mohammad Abdul Hai Siddique, Kimio Satoh, Ryo Kurosawa, Md. Elias Al-Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Hiroaki Shimokawa (2017): Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds. Accepted for oral presentation during the Young Investigator’s Award for International Students Finalists Lecture at the 81st  Annual Scientific Meeting of Japanese Circulation Society in Kanazawa, Japan; March 17-19.
  • Mohammad Abdul Hai Siddique, Kimio Satoh, Ryo Kurosawa, Md. Elias Al-Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Hiroaki Shimokawa (2016): Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds. Poster (Number: T4238, category: 14.72) presented at Scientific sessions by American Heart Association (AHA) in New Orleans, Louisiana, USA; November 12-16.
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa,  Shinichiro Sunamura, Masamichi Nogi, Tomohiro Otsuki, Kazuhiko Numano, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Shunsuke Tatabe, Tatsu Aoki, Hiroaki Shimokawa (2016): Thrombin Activatable Fibrinolysis Inhibitor Promotes Development of Chronic Thromboembolic Pulmonary Hypertension-A Possible Novel Therapeutic Target. Abstract Rapid Fire oral (Latest in CTEPH and RV Dysfunction Session, category: 14.72) presented at Scientific sessions by American Heart Association (AHA) in New Orleans, Louisiana, USA; November 12-16.
  • Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Kazuhiko Numano, Kota Suzuki, Mohammad Abdul Hai Siddique, Elias Al-Mamun, Hiroaki Shimokawa (2016): Celastramycin Inhibits Pulmonary Arterial Smooth Muscle Cell Proliferation and Ameliorates Hypoxia-induced Pulmonary Hypertension in Mice. Poster (Number: T5266, category: 14.72) presented at Scientific sessions by American Heart Association (AHA) in New Orleans, Louisiana, USA; November 12-16.
  • Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Sato, Masamichi Nogi, Numano Kazuhiko, Mohammad Abdul Hai Siddique, Md. Elias Al-Mamun, Syunsuke Tatebe, Tatsui Aoki, Koichiro Sugimura, Hiroaki Shimokawa (2016): Development of new therapeutic agent for pulmonary hypertension by compound screening. Japanese pulmonary hypertension, pulmonary circulation society (JPHCS) 1st scientific meeting; Tokyo, Japan, OR5-5(Fundamentals of pulmonary hypertension, pulmonary circulation) (Oct 1-2).
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa,  Elias Al-Mamun, Mohammad Abdul Hai Siddique, Shinichiro Sunamura, Hiroaki Shimokawa (2016): Involvement of TAFI is a new mechanism for the pathogenesis of chronic thromboembolic pulmonary hypertension. Japanese pulmonary hypertension, pulmonary circulation society (JPHCS) 1st scientific meeting; Tokyo, Japan, OR5-9 (Fundamentals of pulmonary hypertension, pulmonary circulation) (Oct 1-2).
  • Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Sato, Masamichi Nogi, Numano Kazuhiko, Mohammad Siddique, Elias Al-Mamun, Koichiro Sugimura, Hiroaki Shimokawa (2015): Development of new therapeutic agent for pulmonary hypertension by compound screening. Japanese pulmonary circulation society 4th scientific meeting; Tokyo, OR2-3(PAH1) (Oct 3-4).
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Satoshi Miyata, Yoshihiro Fukumoto and Hiroaki Shimokawa (2015):   Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension through synergistic inhibition of Rho-kinase.  Accepted for oral presentation during the Young Investigator’s Award for International Students Finalists Lecture at the 79th Annual Scientific Meeting of Japanese Circulation Society in Osaka; April 24-26.
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Satoshi Miyata, Yoshihiro Fukumoto and Hiroaki Shimokawa (2014):   Combination Therapy with Fasudil and Sildenafil Exerts Synergistic Effects Through Inhibition of Rho-kinase in Pulmonary Hypertension.  Accepted for poster presentation at the 78th Annual Scientific Meeting of Japanese Circulation Society in Tokyo; March 21-23.
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Md. Elias-Al-Mamun, Hiroaki Shimokawa (2013):  Molecular and cellular mechanisms of right ventricular remodeling in pulmonary hypertension.  Poster (Number: 11935) presented at Scientific sessions by American Heart Association (AHA) in Dallas, TX, USA; November 16̴20.
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Yoshihiro Fukumoto and Hiroaki Shimokawa (2013). Combination Therapy with Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. Circ J. 77 (Suppl I): PE-415; 1766
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Md. Elias-Al-Mamun, Hiroaki Shimokawa (2013):  Impact of endothelial nitric oxide synthase on the development of right ventricular dysfunction caused by pulmonary hypertension.  Circ J. 77 (Suppl I): PE-413; 1764.
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Yoshihiro Fukumoto and Hiroaki Shimokawa (2013). Combination Therapy with Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. Japanese pulmonary circulation society 2nd scientific meeting. O-25.
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Md. Elias-Al-Mamun, Hiroaki Shimokawa (2013):  Impact of endothelial nitric oxide synthase on the development of right ventricular dysfunction caused by pulmonary hypertension.  Japanese pulmonary circulation society 2nd scientific meeting; Tokyo, O-22.

 

Oral Presentations:

 

  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa, Shinichiro Sunamura, Masamichi Nogi, Tomohiro Otsuki, Satoshi Miyata, Hiroaki Shimokawa (2017): Thrombin Activatable Fibrinolysis Inhibitor Promotes Development of Chronic Thromboembolic Pulmonary Hypertension-A Possible Novel Therapeutic Target. Young Investigator Award Session Basic Science Finalist Lecture ( presentation number 1983) presented at scientific congress by European Society of Cardiology (ESC) in Fira Gran Via, Barcelona, Spain; August 26-30.
  • Mohammad Abdul Hai Siddique, Kimio Satoh, Ryo Kurosawa, Md. Elias Al-Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Hiroaki Shimokawa (2017): Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds. Accepted for oral presentation during the Young Investigator’s Award for International Students Finalists Lecture at the 81st  Annual Scientific Meeting of Japanese Circulation Society in Kanazawa, Japan; March 17-19.
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa,  Shinichiro Sunamura, Masamichi Nogi, Tomohiro Otsuki, Kazuhiko Numano, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Shunsuke Tatabe, Tatsu Aoki, Hiroaki Shimokawa (2016): Thrombin Activatable Fibrinolysis Inhibitor Promotes Development of Chronic Thromboembolic Pulmonary Hypertension-A Possible Novel Therapeutic Target. Abstract Rapid Fire oral (Latest in CTEPH and RV Dysfunction Session, category: 14.72) presented at Scientific sessions by American Heart Association (AHA) in New Orleans, Louisiana, USA; November 12-16.
  • Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Sato, Masamichi Nogi, Numano Kazuhiko, Mohammad Abdul Hai Siddique, Md. Elias Al-Mamun, Syunsuke Tatebe, Tatsui Aoki, Koichiro Sugimura, Hiroaki Shimokawa (2016): Development of new therapeutic agent for pulmonary hypertension by compound screening. Japanese pulmonary hypertension, pulmonary circulation society (JPHCS) 1st scientific meeting; Tokyo, Japan, OR5-5(Fundamentals of pulmonary hypertension, pulmonary circulation) (Oct 1-2).
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa,  Elias Al-Mamun, Mohammad Abdul Hai Siddique, Shinichiro Sunamura, Hiroaki Shimokawa (2016): Involvement of TAFI is a new mechanism for the pathogenesis of chronic thromboembolic pulmonary hypertension. Japanese pulmonary hypertension, pulmonary circulation society (JPHCS) 1st scientific meeting; Tokyo, Japan, OR5-9 (Fundamentals of pulmonary hypertension, pulmonary circulation) (Oct 1-2).
  • Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Sato, Masamichi Nogi, Numano Kazuhiko, Mohammad Siddique, Elias Al-Mamun, Koichiro Sugimura, Hiroaki Shimokawa (2015): Development of new therapeutic agent for pulmonary hypertension by compound screening. Japanese pulmonary circulation society 4th scientific meeting; Tokyo, OR2-3(PAH1) (Oct 3-4).
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Satoshi Miyata, Yoshihiro Fukumoto and Hiroaki Shimokawa (2015):   Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension through synergistic inhibition of Rho-kinase.  Accepted for oral presentation during the Young Investigator’s Award for International Students Finalists Lecture at the 79th Annual Scientific Meeting of Japanese Circulation Society in Osaka; April 24-26.
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Yoshihiro Fukumoto and Hiroaki Shimokawa (2013). Combination Therapy with Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. Japanese pulmonary circulation society 2nd scientific meeting. O-25.
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Md. Elias-Al-Mamun, Hiroaki Shimokawa (2013):  Impact of endothelial nitric oxide synthase on the development of right ventricular dysfunction caused by pulmonary hypertension.  Japanese pulmonary circulation society 2nd scientific meeting; Tokyo, O-22.

 

Poster Presentations:

  • Md. Elias Al-Mamun, Kimio Satoh, Taijyu Satoh, Nobuhiro Yaoita, Mohammad Abdul Hai Siddique, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa, Shinichiro Sunamura, Masamichi Nogi, Tomohiro Otsuki, Hiroaki Shimokawa (2017): Rivaroxaban Prevents the Development of Chronic Thromboembolic Pulmonary Hypertension in Mice- Novel Beneficial Effects of the FXa Inhibitor. e-Poster presented at Moderated Poster Session (presentation number P4926) at scientific congress by European Society of Cardiology (ESC) in Fira Gran Via, Barcelona, Spain; August 26-30.
  • Masamichi Nogi, Kimio Satoh, Shun Kudo, Junichi Omura, Nobuhiro Kikuchi, Taijyu Satoh, Shinichiro Sunamura, Ryo Kurosawa, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Tomohiro Otsuki, Hiroaki Shimokawa (2017): Protective Roles of small GTP-binding Protein GDP Dissociation Stimulator Against Angiotensin II-induced Thoracic Aortic Aneurysm Formation and Rupture in Mice- A Possible Novel Therapeutic Target. e-Poster presented at Best Poster in Atherosclerosis Session (presentation number P5164) at scientific congress by European Society of Cardiology (ESC) in Fira Gran Via, Barcelona, Spain; August 26-30.
  • Mohammad Abdul Hai Siddique, Kimio Satoh, Ryo Kurosawa, Md. Elias Al-Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Hiroaki Shimokawa (2016): Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds. Poster (Number: T4238, category: 14.72) presented at Scientific sessions by American Heart Association (AHA) in New Orleans, Louisiana, USA; November 12-16.
  • Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Kazuhiko Numano, Kota Suzuki, Mohammad Abdul Hai Siddique, Elias Al-Mamun, Hiroaki Shimokawa (2016): Celastramycin Inhibits Pulmonary Arterial Smooth Muscle Cell Proliferation and Ameliorates Hypoxia-induced Pulmonary Hypertension in Mice. Poster (Number: T5266, category: 14.72) presented at Scientific sessions by American Heart Association (AHA) in New Orleans, Louisiana, USA; November 12-16.
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Satoshi Miyata, Yoshihiro Fukumoto and Hiroaki Shimokawa (2014):   Combination Therapy with Fasudil and Sildenafil Exerts Synergistic Effects Through Inhibition of Rho-kinase in Pulmonary Hypertension.  Accepted for poster presentation at the 78th Annual Scientific Meeting of Japanese Circulation Society in Tokyo; March 21-23.
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Md. Elias-Al-Mamun, Hiroaki Shimokawa (2013):  Molecular and cellular mechanisms of right ventricular remodeling in pulmonary hypertension.  Poster (Number: 11935) presented at Scientific sessions by American Heart Association (AHA) in Dallas, TX, USA; November 16̴20
  • Md. Elias-Al-Mamun, Kimio Satoh, Shin-ichi Tanaka, Toru Shimizu, Suvd Nergui, Yoshihiro Fukumoto and Hiroaki Shimokawa (2013). Combination Therapy with Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. Circ J. 77 (Suppl I): PE-415; 1766
  • Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Md. Elias-Al-Mamun, Hiroaki Shimokawa (2013):  Impact of endothelial nitric oxide synthase on the development of right ventricular dysfunction caused by pulmonary hypertension.  Circ J. 77 (Suppl I): PE-413; 1764.

Conference / Training Attended

The Scientific Sessions by American Heart Association (AHA) (2017)
             Place: Anaheim International Convention center, Anaheim, California, USA.
Date: November 11—November 15.
 
The Scientific Congress by European Society of Cardiology (ESC) (2017)
Place: Fira Gran Via, Barcelona, Spain.
Date: August 26—August 30.
 
The 81st Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2017)
 Place: Ishikawa Ongakudo, Kanazawa, Japan. 
 Date: March 17 – March 19.
 
The Scientific Sessions by American Heart Association (AHA) (2016)
Place: Ernest N. Morial Convention center, New Orleans, Louisiana, USA.
Date: November 12—November 16.
 
The 80th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2016)
Place: Sendai International Centre, Sendai, Japan. 
Date: March 18 -- March 20.
 
The 79th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2015)
Place: Osaka International Convention Centre, Osaka, Japan. 
Date: April 24 -- April 26.
 
The 78th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2014)
Place: Tokyo International Forum, JP TOWER, and Tokyo Chamber of Commerce and Industry, Tokyo, Japan. 
 Date: March 21 -- March 23.
 
The Scientific Sessions by American Heart Association (AHA) (2013)
 Place: Dallas Convention center, Dallas, Texas, USA.
 Date: November 16—November 20.
 
The 2nd Scientific Meeting of the Japanese Pulmonary Circulation Society (JPCS) (2013)
 Place: Tokyo Station Conference, Tokyo, Japan. 
 Date: June 22 -- June 23.
 
The 77th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2013)
 Place: Pacifico Yokohama, Japan. 
 Date: March 15 -- March 17.
 
The Scientific Sessions by American Heart Association (AHA) (2012)
 Place: LosAngeles, California, USA.
 Date: November 3—November 7.
 
The 76th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2012)
  Place: Fukuoka International Congress Centre, Japan. 
  Date: March 16 -- March 18.
 
The Scientific Sessions by American Heart Association (AHA) (2011)
  Place: Orange County Convention Centre, Orlando, Florida, USA. 
  Date: November 12—November 16.
 
Fifty-Eighth Law and Administration Course by Bangladesh Civil Service Academy (2006)
  Place: Bangladesh Civil Service Administration Academy, Shahbag, Dhaka.
  Date: July 31-- December 30
 
Management Development Programme for Bangladesh Civil Servants India Module (2006)
   Place: Indian Institute of Public Administration (IIPA), Delhi, India
   Date: June 19-- June 25.
 
Thirty-Sixth Foundation Training Course by BPATC (2005-2006)
    Place: Bangladesh Public Administration Training Centre (BPATC),Savar, Dhaka
    Date: November 13, 2005 -- March 12, 2006.
 
Rural Development And Poverty Alleviation Training Program by BRDTI (2006)
     Place: Bangladesh Rural Development Training Institute (BRDTI), Sylhet
     Date: January 15-- January 20.
 
Management Training Programme on Global Compact for Managers/Diorectors organized by Bangladesh Employers’ Federation (BEF) and International Labour Organisation (ILO) (2003)
     Place: Motijheel, Dhaka
     Date: May 04-- May 05.
 
In-plant training program from Aventis Pharma, imparted by Department of Pharmacy, University of Dhaka, as a course requirement of Bachelor of Pharmacy (2002)
     Place: Aventis Pharma Plant, Gazipur, Dhaka, Bangladesh
     Date: February 07--February 20.

 

Professional Memberships

  • Member of Bangladesh Pharmacy Council (BPC) License No: A-2231
  • Pharmacy Graduates' Association (PGA), Bangladesh
  • Bangladesh Pharmaceutical Society (BPS)
  • Dhaka University Pharmaceutical Society (DUPS)
  • BCS Administrative Service Association (ID No-15518)
  • Member of Japanese Circulation Society (JCS) (No: 139570)

Awards Received

  •  2017: Junior Investigator Travel Award by American Heart Association (AHA) at Anaheim, California, USA on November 14, 2017.
  • 2014-2018: JSPS Postdoctoral Fellowship for Foreign Researchers (Pathway to University Positions in Japan) at Tohoku University in Japan (November 22, 2014 to December 31, 2014; and March 1, 2016 to January 22, 2018).
  • 2015: Young Investigator’s Award for International Students by Japanese Circulation Society at Osaka, Japan on April 24-26, 2015.
  • 2009-2014:  Japanese Government (MONBUKAGAKUSHO: MEXT) Scholarship for PhD Study at Tohoku University in Japan (From October 2009 to March 2014).
  • 2000: University Merit Scholarship for achieving First Class First position in M. Pharm (2000) examination at Dhaka University.
  • 1999: University Merit Scholarship for achieving First Class Second position in B. Pharm (1999) examination at Dhaka University.
  • 1995-1999: Board Scholarship by Ministry of Education, Bangladesh for getting better marks in Higher Secondary School Certificate (H.S.C.) examination 1994.
  • 1992-1994: Board Scholarship by Ministry of Education, Bangladesh for getting better marks in Secondary School Certificate (S.S.C.) examination 1992.
  • 1990-1991:  Govt. Scholarship by Ministry of Education, Bangladesh Scholarship in junior school held in the eighth year of schooling’ 1989.
  • 1987-1989:  Govt. Scholarship by Ministry of Education, Bangladesh Scholarship in primary school held in the fifth year of schooling’ 1986.

Research Experience:

  • Post-Doctoral Research (Under JSPS Fellowship, JAPAN) - Dept. of Cardiovascular Medicine, Tohoku University, Japan; Nov 2014-Dec 2014; Mar 2016-Jan 2018 (Supervisor: Prof. Hiroaki Shimokawa, MD, PhD)
  • Development of pulmonary hypertension or right ventricular failure in animal model
  • Investigation of drug efficacy on monocrotaline-induced and sugen-hypoxic pulmonary hypertension in rats
  • Development of pulmonary hypertension using hypoxia with genetically modified mice.
  • Management of mice including breeding, mating and producing genetically modified mice.
  • Analysis of different methods used in pulmonary hypertension model including hemodynamics, histology analysis, western blotting, echocardiography and survival.
  • In vitro study with different cells including HPASMC, HPAEC or primary cell culture etc.
  • Doctoral Research (Under MEXT Scholarship, JAPAN) - Dept. of Cardiovascular Medicine, Tohoku University, Japan; 2009-2014 (Supervisor: Prof. Hiroaki Shimokawa, MD, PhD)
    • Development of pulmonary hypertension or right ventricular failure in animal model
    • Investigation of drug efficacy on monocrotaline-induced pulmonary hypertension in rats
    • Analysis of different methods used in pulmonary hypertension model including hemodynamics, histology analysis, western blotting, echocardiography and survival.
  • As a supervisor / co-supervisor of Master’s Research Student - Dept. of Pharmaceutical Technology, University of Dhaka, Bangladesh; 2006-2009 (Supervisor: Prof. Dr. Reza-ul Jalil)
    • Formulation and development of sustained release tablets of ciprofloxacin
    • Development and Evaluation of Combined Gliclazide and Enalapril Maleate Immediate Release Tablet
    • Preparation and Characterization of Lidocaine Double Layer Buccal Tablet
    • Investigation of in vitro drug release kinetics from this tablet
    • Research on pharmaceutical marketing
  • Graduate / Master’s Research - Dept. of Pharmaceutical Technology, University of Dhaka, Bangladesh; 2003-2004 (Supervisor: Prof. Dr. Reza-ul Jalil)
    • Formulation and development of biodegradable in situ implants
    • Investigation of in vitro drug release kinetics from this implant
    • Analysis of dissolution behavior and kinetics
  • Undergraduate / Honors Research - Dept. of Pharmacy, University of Dhaka, Bangladesh; 2000-2002 (Supervisor: Dr. Monira Ahsan)
    • Extraction of crude material from plant
    • Phytochemical investigation on crude extracts from Hedyotis corymbosa
    • Biological investigation on crude extracts from Hedyotis corymbosa

 

Research Interest

  • Cardiovascular Molecular Biology (Pulmonary hypertension)
  • Drug Delivery System such as Sustained Release technology, Implantation technology, Nanotechnology, Lipid drug delivery, Bioavailability enhancing technology, Combination dosage form.
  • Pharmaceutical marketing and Public health related research/activities
  • Molecular-based formulation of solid-state pharmaceutics
  • Natural Product chemistry or phytochemical work.
      

 

Conference / Training Attended

The Scientific Sessions by American Heart Association (AHA) (2017)
             Place: Anaheim International Convention center, Anaheim, California, USA.
Date: November 11—November 15.
 
The Scientific Congress by European Society of Cardiology (ESC) (2017)
Place: Fira Gran Via, Barcelona, Spain.
Date: August 26—August 30.
 
The 81st Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2017)
 Place: Ishikawa Ongakudo, Kanazawa, Japan. 
 Date: March 17 – March 19.
 
The Scientific Sessions by American Heart Association (AHA) (2016)
Place: Ernest N. Morial Convention center, New Orleans, Louisiana, USA.
Date: November 12—November 16.
 
The 80th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2016)
Place: Sendai International Centre, Sendai, Japan. 
Date: March 18 -- March 20.
 
The 79th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2015)
Place: Osaka International Convention Centre, Osaka, Japan. 
Date: April 24 -- April 26.
 
The 78th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2014)
Place: Tokyo International Forum, JP TOWER, and Tokyo Chamber of Commerce and Industry, Tokyo, Japan. 
 Date: March 21 -- March 23.
 
The Scientific Sessions by American Heart Association (AHA) (2013)
 Place: Dallas Convention center, Dallas, Texas, USA.
 Date: November 16—November 20.
 
The 2nd Scientific Meeting of the Japanese Pulmonary Circulation Society (JPCS) (2013)
 Place: Tokyo Station Conference, Tokyo, Japan. 
 Date: June 22 -- June 23.
 
The 77th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2013)
 Place: Pacifico Yokohama, Japan. 
 Date: March 15 -- March 17.
 
The Scientific Sessions by American Heart Association (AHA) (2012)
 Place: LosAngeles, California, USA.
 Date: November 3—November 7.
 
The 76th Annual Scientific Meeting of the Japanese Circulation Society (JCS) (2012)
  Place: Fukuoka International Congress Centre, Japan. 
  Date: March 16 -- March 18.
 
The Scientific Sessions by American Heart Association (AHA) (2011)
  Place: Orange County Convention Centre, Orlando, Florida, USA. 
  Date: November 12—November 16.
 
Fifty-Eighth Law and Administration Course by Bangladesh Civil Service Academy (2006)
  Place: Bangladesh Civil Service Administration Academy, Shahbag, Dhaka.
  Date: July 31-- December 30
 
Management Development Programme for Bangladesh Civil Servants India Module (2006)
   Place: Indian Institute of Public Administration (IIPA), Delhi, India
   Date: June 19-- June 25.
 
Thirty-Sixth Foundation Training Course by BPATC (2005-2006)
    Place: Bangladesh Public Administration Training Centre (BPATC),Savar, Dhaka
    Date: November 13, 2005 -- March 12, 2006.
 
Rural Development And Poverty Alleviation Training Program by BRDTI (2006)
     Place: Bangladesh Rural Development Training Institute (BRDTI), Sylhet
     Date: January 15-- January 20.
 
Management Training Programme on Global Compact for Managers/Diorectors organized by Bangladesh Employers’ Federation (BEF) and International Labour Organisation (ILO) (2003)
     Place: Motijheel, Dhaka
     Date: May 04-- May 05.
 
In-plant training program from Aventis Pharma, imparted by Department of Pharmacy, University of Dhaka, as a course requirement of Bachelor of Pharmacy (2002)
     Place: Aventis Pharma Plant, Gazipur, Dhaka, Bangladesh
     Date: February 07--February 20.

 

Professional Memberships

  • Member of Bangladesh Pharmacy Council (BPC) License No: A-2231
  • Pharmacy Graduates' Association (PGA), Bangladesh
  • Bangladesh Pharmaceutical Society (BPS)
  • Dhaka University Pharmaceutical Society (DUPS)
  • BCS Administrative Service Association (ID No-15518)
  • Member of Japanese Circulation Society (JCS) (No: 139570)