Dr. Biplab Kumar Das

Ph.D. (Japan), Post-doc (JSPS fellow, Japan)

Professor, Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh. Email: bkdas72@yahoo.com; bkdas72@du.ac.bd; Cell: +880-1720051994. Address: Apt-B-2, 180 Green Road, Dhaka-1205, Bangladesh

Professional Summary

Enthusiastic, dedicated and highly motivated University Teacher with over 18 years of research experience on medicinal chemistry especially on the synthesis of bioactive organic compounds and their structural elucidation using a combination of chromatographic and spectroscopic analytical methods, development of synthetic methods of APIs, isolation, purification and pharmacological/biological evaluation of both natural and synthetic products

Qualifications

Teaching, tutoring and counseling

Grant writing and project management

Research goal setting and implementation

Development of multi-step synthetic methods for organic synthesis

Qbd (Quality by Design) based optimization of synthetic methods for APIs

Interpretation and analysis of spectral data for structural elucidation of unknown organic compounds

Operating advanced instruments like HPLC, LC-MS, FT-IR, NMR and Mass spectrometers.

Extensive experience in PC, using different software like SPSS, different types of chemical and biological database

Animal handling for studying pharmacological activities

Studying cytotoxic and antimicrobial activities using BSLA and Disc-diffusion assay

Teaching/Professional Experience           

April 2013 to Current               

Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Bangladesh

January 2009 to April 2013              

Associate Professor, Department of Pharmacy, North South University, Dhaka, Bangladesh

September 2006 to December 2008                      

Assistant Professor, Department of Pharmacy, East West University, Dhaka, Bangladesh

June 2004 to August 2006

Post-doctoral Research Fellow, Japan Society for Promotion of Science (JSPS) Program, Department of Frontier Materials, Nagoya Institute of Technology, Nagoya City, Japan

August 2002 to May 2004       

Assistant Professor, Department of Pharmacy, Faculty of Life Sciences, University of Development Alternative (UODA), Dhaka, Bangladesh

July 1997 to September 1998          

Lecturer, Department of Pharmacy, University of Dhaka, Bangladesh

Administrative Position

Feb 26, 2013 – April 20, 2013 Chairman, Department of Pharmacy, North South University.

Education

Ph.D. (Doctor of Philosophy)  2002  

Faculty of Pharmaceutical Sciences, Toyoma Medical and Pharmaceutical University, Toyoma, Japan. Major: Organic Synthesis (Medicinal Chemistry)

Ph.D. dissertation: Design and syntheses of novel class of peptides having nonpolar nucleobase residues. Supervisor: Professor Dr. Norio Shibata

Master of Pharmacy (M. Pharm) 1996

Department of Pharmacy, University of Dhaka, Bangladesh

Result: 1st class 1st position

Thesis: Hepatoprotective and anti-viral activities of Phyllanthus reticulatus

Supervisor: Professor Dr. A. K. Azad Chowdhury

Bachelor of Pharmacy (B.Pharm) 1994

Department of Pharmacy, University of Dhaka, Bangladesh

Result: 1st class 1st position

Membership/Affiliations

Member, Bangladesh Pharmaceutical Society

Member, Pharmacy Graduate’s Association, Bangladesh

Member, Japan Society for the promotion of Sciences, Japan

Registered Pharmacist (A-grade), Bangladesh Pharmacy Council

Member, Governing body, Dhaka Central International Medical College, Ring Road, Dhaka.

Scholarships, Fellowships and Awards

JSPS post-doctoral fellowship at Nagoya Institute of Technology, Japan

Monbusho Scholarship for Ph.D. study at Toyama Medical and Pharmaceutical University, Japan

Science and Technology Fellowship awarded by Govt. of Bangladesh for conducting research work at Masters Level 

Academic scholarship for outstanding result in Bachelors and Masters Examination

Merit scholarships for outstanding results in S.S.C and H.S.C examinations

Awarded gold medal by District Education Foundation, Natore for the outstanding Result (1st class 1st) in Masters Examination

Research Interests

Design and syntheses of novel biologically active compounds from existing smaller molecules

Synthesis and oligomerization of nonpolar nucleobase peptides/nonpolar PNA monomers with antisense properties

Qbd-based commercial synthesis method development of active pharmaceutical ingredients (APIs)

Phytochemical and pharmacological investigation of tropical plants of Bangladesh

Current Research Projects

Design and synthesis of novel benzimidazole derivatives with potential biological activities: A number of novel benzimidazole derivatives are being synthesized currently in order to investigate potential biological activities.

Commercial scale synthesis method development for Proton Pump Inhibitor (PPI) raw materials by applying Qbd-based reverse engineering technology: This project is funded by World Bank under conduction of University Grants Commission, Bangladesh. The research project is being currently pursued for the commercial synthesis method development of one of the most commonly used APIs like PPIs (omeprazole, esomeprazole, pantoprazole, rabeprazole) by using Qbd-based reverse engineering technology. Some Qbd methods have been optimized and applied for the synthesis of omeprazole in pilot scale with high yields. The research is being carried out in collaboration with Marshal University, West Virginia, USA.

Research Experience

●Syntheses of N-nonpolar nucleobase dipeptides by Ugi four- component condensation reaction: A novel class of a,a- and a,b-dipeptides having fluoroaromatic group appended to the nitrogen atom were synthesized by a single-step one-pot synthesis based on the Ugi four-component condensation.

●Syntheses of peptide nucleic acid (PNA) monomers containing fluoroaromatics: Two novel classes of peptide nucleic acid monomers containing fluoroaromatics designated as F-PNA and b-F-PNA were synthesized using conventional peptide coupling methods.

●Synthesis of novel fluorophenylaryl/heteroaryl ether derivatives as selective cox-2 inhibitors: A novel class of fluorophenylaryl / heteroaryl ether derivatives were synthesized by using a variety of convenient phenolic coupling methods and subsequent hydrogenation of the coupled intermediates. The compounds synthesized are structurally similar to a number of anti-inflammatory agents.

●Synthesis of minor tautomeric isosteres of natural nucleosides as a means of studying the correlation of the tautomerization of nucleotides with DNA replication: Two minor tautomeric isosteres of natural nucleosides were synthesized where the bases used are the closest possible steric and electronic mimics of protonated enol forms of thymine and guanine (T*+ and G*+) respectively. Both the compounds were characterized as the b-anomer with the help of spectroscopic data. The 1H NMR data was matched with the data of similar known compound and the configuration was confirmed by NOE experiment.

●Enanatioselective fluorination of carbonyl compounds mediated by cinchona alkaloid derivatives/selectfluor combination: A number of carbonyl compounds were tried for enantioselective fluorination by using the combination of cinchona alkaloids/selectfluor. The fluorinated compounds were obtained in moderate yields with poor enantiomeric excess (ee).

●Total Synthesis of fluoroisosteric analogues of biologically active natural Product CJ-12662: A novel fluoroisosteric analogue of the core structure of pyrrolobenzoxazine terpenoid natural product CJ-12662 was tried to synthesize from L-Tryptophan by a combination of N-fluoro-2, 4, 6-trimethyl triflate (FTP) mediated fluorination and a Meisenheimer-type rearrangement. The product was obtained in moderate yield.

●Bioactivity guided phytochemical and pharmacological evaluation of tropical plants: The tropical having known or unknown traditional medicinal uses are studied for the presence of phytochemicals in the crude extract of the whole plant or plant parts. The crude extracts are then subjected to a preliminary bioactivity study. The biologically active extracts of fractions are evaluated for several pharmacological activities like cytotoxic, antibacterial, analgesic, anti-inflammatory, antioxidant etc. The extract or fraction is tried to purify by column chromatography or HPLC in order to isolate the compound responsible for bioactivity.

Publications

1. B. Das, S. Alam, A. Uddin, JMA Hannan, R. Bhattacherjee, B. K. Das (2015): Analagesic and Anti-inflammatory activity of the Hydroalcoholic extract of Euphorbia antiquorum Linn. American J. Pharmacol. Toxicol.10 (2):46-55.

2. A. Sarwer, T.B. Haque, T. Malik, B. K. Das (2015): Antioxidant and Analgesic Activities of Ethanol Leaf Extract of Brownea coccinea. Adv. Med. Plant. Res., 3(2):69-74.

3. B.K. Das, M. M. Al-Amin, N. N. Chowdhury, M.F. Majumder, M.N. Uddin and M.A. Pavel (2015): Analgesic, anti-inflammatory, and anti-oxidant activities of Phlogacanthus thyrsiflorus leaves. J Basic Clin Physiol Pharmacol, 26(2): 153-9.

4. S. Haque, S.D.  Lopa, B. K. Das (2015): Evaluation of Antioxidant Potential of Spilanthes Paniculata. Int. J. Pharmacy Pharm. Sci. 7(8):390-392.

5. S. Haque, L. Sharmin, B. K. Das (2015): Phytochemical investigation and evaluation of analgesic activity Willughbeia edulis roxb available in Bangladesh. Int. Res. J. Pharm. 6(7): 407-410.

6. T. M. Talha, S. Hoque, L. Sharmin, B. K. Das (2015): Phytochemical investigation and evaluation of analgesic activity of Sonneratia caseolaris. Stamford J. Pharm. Sci. 7(1 & 2): 11-16.

7. F. K. Arpita, N.H.M. Masum, B. K. Das (2015): Analgesic and Anti-inflammatory activity of ethanol extract of Leucas aspera. Stamford J. Pharm. Sci. 6 (1&2): 33-40.

8. T. Kibria, B. K. Das, T.Hasan, M. A.Uddin, M. M. Alam (2014): Phytochemical screening and evaluation of analgesic activity of Solanum surattense. American. J. Pharm. Sci. & Nanotechnology, 1(1): 1-10.

9. B. K. Das, M. S. Hossain, U. K. Fatema, R. Rahman, M. A. Akbar, F. Uddin (2014): Analgesic and anti-inflammatory activities of the fruit extract of Ampelocissus latifolia (Roxb) on laboratory animals. British J. Pharm. Res., 4(12): 1477-1485.

10. B. K. Das, U. K. Fatema, M. S. Hossain, R. Rahman, K. Fatema (2014): Anti-inflammatory and analgesic activities of fruit extract of Alpinia nigra on laboratory animals. Eur J. Med. Plants, 4(10):1158-1166.

11. B. K. Das, K. Ahmed, A. Uddin, R. Bhattacherjee, M. A. Amin (2014): Antinociceptive activity of methanol extract of Spilanthes paniculata. Turkish J. Pharm. Sci., 11(2): 137-144.

12. S. A. Adnan, M. M. Al-Amin, M. M. Nasir Uddin, M. Shohel, R. Bhattacharjee, J.M.A. Hannan, B. K. Das (2014): Analgesic, anti-inflammatory and antipyretic effects of Ixora Coccinea. J. Basic and Clinical Physiology and Pharmacology, 25(4): 423-428.

13. B.K. Das, M. M. Al-Amin, S. M. Russel, S. Kabir, R. Bhattacherjee and J.M.A. Hannan (2014): Phytochemical Screening and Evaluation of Analgesic Activity of Oroxylum indicum. Indian J. Pharm. Sci., 76(6), 571-575. 

14. P.M.H. Yousuf, N.Y. Noba, M. Shohel, R. Bhattacherjee, B.K. Das (2013): Analgesic, Anti-inflammatory and Antipyretic Effect of Mentha spicata (Spearmint). British J. Pharm. Res., 3(4), 854-864.

15. B. K. Das, M. M. Bin Hasan, S. Saha, R. Ahsan, JMA Hannan, R. Bhattacharjee (2013): Evaluation of Cytotoxic Activity of Paederia foetida Extracts. Bangladesh J. Med. Sci. 19(2):105-108.

16. B. K. Das, A. Haque, S. K. Sen, M. Shohel, R.  Bhattacharjee (2013): Analgesic and Anti-inflammatory Activity Study of the Methanol Extract of Solanum surattense (Solanaceae). Bangladesh J. Med. Sci. 19(1):13-15.

17. B. Das, T. Ferdous, Q. A. Mahmud, JMA Hannan, R. Bhattacherjee, B. K. Das (2012): Antinocicpetive and anti-inflammatory activity of the bark extract of Plumeria rubra. European J. Med. Plants, 3(1), 114-126.

18. D.K. Saha, B. K. Das, S. C. Bachar, B. K. Datta (2012): Synthesis and antitubercular activity of some indanyl thiosemicarbazone derivatives. J. Pharm. Res. Opinion. 2(10), 125-128.

19. S. Halder, M. Hasan, B. K. Das, A.K.L. Kabir, A.S.S. Rouf (2012): In vitro Release Study of Carvedilol Phosphate Matrix Tablets Prepared with Hydroxypropyl Methylcellulose. Trop. J. Pharm. Res., 11 (3), 379-386.

20. B. K. DAS, S. Bepary, B.K. Datta, ASS Rouf, M.S. Ali, A.K.A. Chowdhury (2012): Renoprotective activity of Phyllanthus reticulatus, Bangladesh J. Med. Sci. 18 (2):126-128.

21. R. Bhattacherjee, S. Karimi, S.W. Ali, A. Uddin, JMA Hannan, B.K. Das (2012): Evaluation of the Phytochemical, Cytotoxic, Analgesic and Anti-Inflammatory properties of Azadirachta indica. Bangladesh J. Med. Sci. 18(2): 114-119.

22. B. K. Das, B. Das, F. K. Arpita, M. A. Morshed, A. Uddin, R. Bhattacherjee, JMA Hannan (2011): Phytochemical Screening and Antioxidant Activity OF Leucas aspera. Int. J. Pharm. Sci. Res. 2(7), 1746-1752.

23. JMA Hannan, B. K. Das, A. Uddin, R. Bhattacharjee, B. Das, H.S. Chowdhury, ASM Mosaddek (2011): Analgesic  and anti-inflammatory effects of Ocimum Sanctum (Linn) in laboratory animals. Int. J. Pharm. Sci. Res. 2(8), 2121-2125.

24. T. Hasan, B. K. Das, T. Qibria, M. A. Uddin (2011): Phytochemical Screening and Evaluation of Analgesic Activity of Xanthium Strumarium L. Asian J. Biochem. Pharm. Res. 3(1), 455-463.

25. B. K. Das, J. Firdous, S. Saha, JMA Hannan, R. Bhattacharjee (2011): Antimicrobial Activity of Lagerstroemia speciosa (L) Pers. Leaves. Bangladesh J. Med. Sci. 17(1), 51-55.

26. M. Hasan, B. K. Das, ASS Rouf, S. Halder, ABM Faroque (2011): Trade Related Aspects of Intellectual property Rights and Its Impact on the Pharmaceutical Industry in Bangladesh. Bangladesh J. Med. Sci, 17(2), 139-146.

27. AL Masud, M. Hasan, S. Halder, B. K. Das, ABM Faroque (2011): Quality Control Study of Some Brands of Metformin HCl Modified Release 500 mg Tablets Available in Bangladesh Market. Bang. J. Med. Sci. 17(1), 63-66.

28. B. K. Das, M. Shohel, AM Pavel, N. Akhter, T. Yasmin, R. Bhattacherjee, B. Das, JMA Hannan (2011): Anti-hepatitis B viral activity of Phyllanthus reticulatus. Bangladesh Pharm. Journal, 14(1), 11-14.

29. M. Shohel, B. K. Das, M.M. Rahman, A. Zaman (2011): Review on the Merits and Demerits of Growth Hormone as Anabolic Agent. Bangladesh Pharm. Journal, 14(2), 79-85.

30. JMA Hannan, A. Uddin, S. Khan, S. Ahmed, B.K. Das (2010): Analgesic and Anti-inflammatory effects of Phyllanthus emblica Linn in Laboratory animals, Bangladesh J. Med. Sci., 16 (2), 159-162.

31. A.K.L. Kabir, B. K. Das, A.Z.M. Ruhul Momen, A.S.S.  Rouf (2009): Once Daily Sustained Release Matrix Tablet of Aceclofenac: Formulation and In Vitro Evaluation, Bangladesh Journal of Life Sciences, 21 (1), 121-128. 

32. S. Bepary, B. K. Das, S.C. Bachar, J.K. Kundu, ASS Rouf, B.K. Datta (2008): Anti-inflammatory activity of indanyl tetrazole derivatives. Pak. J. Pharm. Sci. 21(3), 295-298.

33. B. K. Das, S. Bepary, B.K. Datta, ASS Rouf, M.S. Ali, A.K.A. Chowdhury (2008): Hepatoprotective activity of Phyllanthus reticulatus. Pak. J. Pharm. Sci. 21(4), 333-337.

34. B. K. Das, N. Shibata, K. Harada, T. Toru (2007): Synthesis of novel fluorophenylaryl/ heteroaryl ether derivatives. Arkivoc (USA), xvi, 73-82.

35. B. K. Das, N. Shibata, Y. Takeuchi (2002): Design and synthesis of N-nonpolar nucleobase dipeptides: an application of the Ugi reaction for the preparation of dipeptides having fluoroarylalkyl groups appended to the nitrogen atom. J. Chem. Soc., Perkin Trans 1(UK), 197-206.

36. N. Shibata, B. K. Das, K. Harada, Y. Takeuchi, M. Bando (2001): The studies of the intramolecular C–F---H–N hydrogen bonding using covalently-linked base pair models of F and A. Synlett (Germany), 1755-1758.

37. N. Shibata, B. K. Das, H. Honjo, Y. Takeuchi (2001): Synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics. J. Chem. Soc., Perkin Trans 1(UK), 1605-1611.

38. N. Shibata, B. K. Das, H. Honjo, Y. Takeuchi (2001): Synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics. J. Chem. Soc., Perkin Trans 1(UK), 1605-1611.

39. N. Shibata, B. K. Das, Y. Takeuchi (2000): Application of the Ugi four-component condensation reaction for the synthesis of a,a- and a,b-dipeptides substituted with fluoroarylalkyl pendent groups. J. Chem. Soc., Perkin Trans I (UK), 4234-4236.

40. B. K. Das, M.S. Ali, A.K. Azad Chowdhury (1999): Cytotoxic activity of Phyllanthus reticulatus. Dhaka Univ. J. Biol. Sci., 8(1), 85-88.

41. A.K. Azad Chowdhury, B. K. Das, M.S. Ali (1997): In Vitro Antibacterial Activity of Phyllanthus reticulatus. Bangladesh J. Physiol. Pharmacol., 13 (2), 55-57.

Conference Proceedings

1. Das, B.K.; Fatema, U.K.; Bhattacharjee, R (2014): Analgesic and Anti-inflammatory activities of some tropical plants in Bangladesh. 1st International congress of the Society for Ethnopharmacology, Porur, Chennai, India, 7-9 march, 2014 (Oral presentation in English).

     2. Das, B.K.; Saha, S.; Ferdous, J.; Hannan. JMA. Bashar SAM (2010): Antimicrobial activity of tropical plants in the treatment of infectious diseases. The 4th Ditan International Conference on Infectious Diseases, Beijing. China, 15 -18 July 2010, 14 (2), S13 (Oral presentation in English).

3.  Das, B. K.; Nozaki, T.; Nakamura, S.; Shibata, N.; Toru, T (2005):  Synthetic Studies of the fluoroisosteric Analogues of CJ-12662. The 36th Annual Meeting of Union of Chemistry-Related          Societies (UCRS) in Chubu Area, Japan, Shizuoka, Japan, September 24, 2005, 36, 179 (Oral presentation in English).

     4. Attended in the 22nd Summer Seminar on Synthetic Organic Chemistry held on September 6-8, 2005 in Takayama, Japan.

5.   Das, B. K.; Honjo, H.; Shibata, N.; Takeuchi, Y (2001): Synthesis of Nonpolar Peptide Nucleic Acid Monomers Containing Fluoroaromatics. The 21st Symposium on Medicinal Chemistry (10th Annual Meeting of Division of medicinal Chemistry) organized by the Pharmaceutical Society of Japan, Kyoto, Japan, November 29, 2001 (Poster plus oral presentation in English).

6.   Das, B. K.; Harada, K.; Shibata, N.; Takeuchi, Y (2001): Design and Synthesis of nonpolar peptoid and peptide nucleic acid derivatives. The 13th Hokuriku Seminar organized by the Society of Synthetic Organic Chemistry, Kanazawa, Japan, 19 October, 2001 (Oral presentation in English).

7.  Das, B. K.; Harada, K.; Shibata, N.; Takeuchi, Y (2001): Crystal structure of 4-amino-4-(2-fluorophenoxy) benzimidazole: Observation of unexpected intermolecular NH—F hydrogen bonding. The 104th Hokuriku Branch Meetings of the Pharmaceutical Society of Japan, Kanazawa, 16 June, 2001 (Oral presentation in English).

    8. Das, B. K.; Harada, K.; Shibata, N.; Takeuchi, Y (2001): Synthesis of Watson-Crick base-pair mimic model compounds base on F---H hydrogen bonding. The 121st Annual Meetings of the Pharmaceutical Society of Japan, Sapporo, 28—30 March 2001. (Poster presentation in English).

 9. Das, B. K.; Shibata, N.; Takeuchi, Y. (2000): Synthesis of N-(p-fluorophenyl) ethyl peptides. The 120th Annual Meetings of the Pharmaceutical Society of Japan, Gifu, 28—30 March 2000, 120 (2), 89 (Poster presentation in English).

      10. Das, B. K.; Harada, K.; Shibata, N.; Takeuchi, Y. (2000): Design and synthetic studies of biologically active compounds having fluoroaromatics. The 24th fluorine conference of Japan, Kyoto, 21—22 September 2000. (Poster presentation in English) 

     Personal

     Date of birth: January 07, 1972

     Place of birth: Natore, Bangladesh

     Father: Late Birendra Kumar Das (Former Headmaster, Tirail High School, Baraigram, Natore)

     Mother: Basanti Rani Das (Retired Govt. Employee)

     Spouse: Lipy Rani Das

     Marital Status: Married; Father of two sons